What would you expect to happen if the anaphase-promoting complex/cyclosome (APC/C) failed to ubiquitinate securin? The cohesin complex will persist, preventing the cell from entering anaphase. … Specifically, you want to focus on drugs that bind to and inactivate certain proteins, thereby halting cell cycle progression.
What does the anaphase promoting complex do?
The anaphase-promoting complex/cyclosome (APC/C) is a multisubunit ubiquitin-protein ligase that targets for degradation cell-cycle regulatory proteins during exit from mitosis and in the G1 phase of the cell cycle.
How does the anaphase promoting complex activated chromatid separation?
In anaphase, activation of anaphase-promoting complex (APC) induces segregation of chromosomes and exit from mitosis by catalyzing the proteolytic destruction of securin and cyclins. … This suggests that CDK1/cyclin B negatively regulates cytokinesis.
What is the function of anaphase promoting complex APC )? Quizlet?
What is the function of the anaphase-promoting complex (APC)? – The APC acts with the cdc20 activator in order to ubiquitinate securin, marking it for degradation. This liberates separase, which cleave cohesin and allos sister chromatids to separate in anaphase.
Which of following is the main function of APC anaphase promoting complex during cell division?
Option d: Anaphase promoting complex (APC) helps in the transition of the chromosome from metaphase to anaphase. The role of APC is that it attaches to the chromosomes aligned at the equator during metaphase and allows the segregation of the chromatids.
What is one of the roles of the APC C during anaphase?
What is one of the roles of the APC/C during anaphase? To directly target the mitotic cyclins for destruction. … The cohesin complex will persist, preventing the cell from entering anaphase.
What is the function of telophase?
Telophase is the fifth and final phase of mitosis, the process that separates the duplicated genetic material carried in the nucleus of a parent cell into two identical daughter cells. Telophase begins once the replicated, paired chromosomes have been separated and pulled to opposite sides, or poles, of the cell.
What is CDK in mitosis?
Mitotic CDKs are best known for their essential function in initiating mitosis, where they promote mitotic spindle formation, chromosome condensation, and the breakdown of the nuclear envelope (Nigg 2001; Miele 2004).
Which of the following consequences is expected to occur if the anaphase promoting complex becomes defective?
Anaphase Promoting Complex (APC) is a protein necessary for separation of daughter chromosomes during anaphase. If APC is defective then the chromosomes will fail to segregate during anaphase.