What is the phenotype and genotype of sickle cell anemia?

Any combination of two of these alleles represents an individual’s genotype. Individuals with genotype AS have the sickle cell trait phenotype, and individuals with SS genotype have the sickle cell disease phenotype.

What is the phenotype of sickle cell anemia?

Sickle cell disorders are associated with variable degrees of anemia depending on genotype, with the most severe decrease in hemoglobin level seen in sickle cell anemia (homozygous hemoglobin S) and the least severe decrease in hemoglobin S-β+ thalassemia.

What are the 3 genotypes for sickle cell anemia?

The predominant genotypes that give rise to SCD include Hb SS, Hb SC, Hb Sβ+-thalassemia and Hb Sβ-thalassemia. Other rare forms include hemoglobin SD and hemoglobin SE.

What are the phenotypic effects of sickle cell anemia?

Deformed, sickled red cells can occlude the microvascular circulation, producing vascular damage, organ infarcts, painful crises and other such symptoms associated with sickle cell disease.

What is the genotype of sickle cell homozygote?

Sickle cell anemia refers to an abnormal homozygote genotype (SS or CC), whereas sickle cell trait refers to heterozygote genotype AS or AC inducing mild disease.

What is phenotype example?

Examples of phenotypes include height, wing length, and hair color. Phenotypes also include observable characteristics that can be measured in the laboratory, such as levels of hormones or blood cells.

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Can 2 sickle cell carriers get married?

When both individuals are sickle cell carriers, the church discourages them from marrying. Some church denominations, especially in Enugu state, go further and refuse to wed couples when both individuals are sickle cell carriers.

How do I know if I have sickle cell anemia?

The best way to check for sickle cell trait or sickle cell disease is to look at the blood using a method called high-performance liquid chromatography (HPLC). This test identifies which type of hemoglobin is present. To confirm the results of HPLC, a genetic test may be done.

What blood type carries sickle cell?

It is an inherited condition in which both hemoglobin A and S are produced in the red blood cells, always more A than S. Individuals with sickle cell trait are generally healthy.

Can sickle cell be cured?

Stem cell or bone marrow transplants are the only cure for sickle cell disease, but they’re not done very often because of the significant risks involved. Stem cells are special cells produced by bone marrow, a spongy tissue found in the centre of some bones. They can turn into different types of blood cells.

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