What is mean by chromatin condensation?

Definition. Chromosome condensation is the dramatic reorganisation of the long thin chromatin strands into compact short chromosomes that occurs in mitosis and meiosis.

Why chromosome condensation is important?

Mitotic chromosome condensation is an essential cellular function ensuring proper compaction and segregation of sister chromatids during cell division. Condensin, a five-subunit complex, conserved among eukaryotes, is the key molecular machine of chromosome condensation.

Does methylation decrease chromatin condensation?

DNA methylation is an important epigenetic mark that is known to induce chromatin condensation and gene silencing. … Reduced DNA backbone rigidity due to the presence of methyl groups is believed to contribute to the observed structural and dynamic differences.

Does acetylation increase chromatin condensation?

H1K85Q acetylation-mimic mutation promotes chromatin condensation. Although H1 lysine 85 (H1K85) may regulate chromatin condensation, how it is involved in this process remains largely unknown.

What is it called when chromosomes appear?

prophase. a cell division begins, the chromatin threads coil and shorten so that visible bar like bodies (chromosomes) appear.

What is meant by condensation?

Condensation is the process where water vapor becomes liquid. It is the reverse of evaporation, where liquid water becomes a vapor. Condensation happens one of two ways: Either the air is cooled to its dew point or it becomes so saturated with water vapor that it cannot hold any more water.

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What happens if chromosomes dont condense?

If they do not align correctly, they cannot move individually to opposite poles in the later phases of mitosis, and the result will be one cell with extra chromosomes and a daughter cell with missing chromosomes. These mutations can lead to harmful results such as cell death, organic disease or cancer.

Does chromatin have RNA?

Whether RNA itself plays a direct structural role in chromatin is, however, not known. Here, we report results indicating that RNA plays a general structural role in eukaryotic chromatin. Our results indicate that purified chromatin contains significant amounts of RNA (2%–5% of total nucleic acids).

What enzyme plays an important role in chromatin condensation?

Overall, current evidence indicates that H2BS10ph plays a major role in chromatin condensation during various cellular processes such as meiosis but the molecular mechanism by which this modification influences chromatin structure still needs to be elucidated.

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