Translocations generally result from swapping of chromosomal arms between heterologous chromosomes and hence are reciprocal in nature (Figure 1) (8,9). DNA double-strand breaks (DSBs) are prerequisites for such translocations, although little is known about their generation.
How common is chromosomal translocation?
Chromosomal translocations refer to exchange of chromosomal segments between chromosomes. Translocations are the most common type of structural chromosomal abnormalities seen in the general population, having a frequency of about 1/1000 live births.
What is an example of translocation?
The translocation in this example is between chromosomes 14 and 21. When a baby is born with this type of translocation chromosome in addition to one normal 14 and two normal 21 chromosomes, the baby will have Down syndrome. This is also called translocation Down syndrome.
Can you have a healthy baby with balanced translocation?
Natural conception and live birth is possible in cases of balanced translocation, but those with the condition may have more difficulty conceiving and are at a greater risk of recurrent miscarriage than those without it.
When does chromosome translocation occur?
Translocations occur when chromosomes become broken during meiosis and the resulting fragment becomes joined to another chromosome. Reciprocal translocations: In a balanced reciprocal translocation (Fig. 2.3), genetic material is exchanged between two chromosomes with no apparent loss.
How can you prevent miscarriage due to chromosomal abnormalities?
Reducing Your Risk of Chromosomal Abnormalities
- See a doctor three months before you try to have a baby. …
- Take one prenatal vitamin a day for the three months before you become pregnant. …
- Keep all visits with your doctor.
- Eat healthy foods. …
- Start at a healthy weight.
- Do not smoke or drink alcohol.
How is balanced translocation treated?
There is no cure for balanced translocation, and in most cases, the only adverse effect on health is recurrent miscarriages. 1 For couples affected by balanced translocation, odds are in favor of a successful pregnancy at some point, but repeated miscarriages can obviously be difficult to cope with emotionally.