The sickle cell anemia trait is found on a recessive allele of the hemoglobin gene. This means that you must have two copies of the recessive allele — one from your mother and one from your father — to have the condition. People who have one dominant and one recessive copy of the allele won’t have sickle cell anemia.
What is an HbS allele?
The HbS allele causes red blood cells to “sickle” instead of forming donut shapes from the HbA version. People with sickle cell trait have some of both. ( Wikimedia Commons) Sometimes carrying a “problem” allele is an advantage—people with the HbS allele are more resistant to malaria! ( Wikimedia Commons)
What are the sickle cell groups?
The Main Types of Sickle Cell Disease:
- Hemoglobin SS Disease. Hemoglobin SS disease is the most common and most severe type of sickle cell disease. …
- Hemoglobin SB 0 (beta zero) Thalassemia. …
- Hemoglobin SC Disease. …
- Hemoglobin SB+ (beta) Thalassemia. …
- Hemoglobin SD, Hemoglobin SE, and Hemoglobin SO.
What blood type is sickle cell trait?
It is an inherited condition in which both hemoglobin A and S are produced in the red blood cells, always more A than S. Individuals with sickle cell trait are generally healthy.
Is Sickle Cell curable?
Stem cell or bone marrow transplants are the only cure for sickle cell disease, but they’re not done very often because of the significant risks involved. Stem cells are special cells produced by bone marrow, a spongy tissue found in the centre of some bones. They can turn into different types of blood cells.
Can a sickle cell patient marry?
The law read in part, “As from the commencement of the law, persons with unqualified Sickle Cell Status Certificate, SCS, shall NOT be married as husband and wife.
Why is sickle cell more common in Africa?
The sickle hemoglobin mutation reached polymorphic frequency in areas of Africa—other origins of the HbS gene were in the Middle East and Indian subcontinent—where malaria was prevalent, as carriers have a survival advantage and are more likely to survive to reproduce.
What type of mutation causes sickle cell anemia?
Types of Changes in DNA
|Class of Mutation||Type of Mutation||Human Disease(s) Linked to This Mutation|
|Point mutation||Substitution||Sickle-cell anemia|
|Insertion||One form of beta-thalassemia|
|Chromosomal mutation||Inversion||Opitz-Kaveggia syndrome|
Where is sickle cell endemic?
Sickle cell trait is more prevalent in people who are of African-descent and also whose ancestors come from tropical and sub-tropical regions where malaria is endemic. The prevalence rates of sickle cell trait in the United States is 9% among African American which is about 3 million people, and 0.2% among Caucasians.
Where on earth is the sickle cell allele selected for?
Sickle cell disease (SCD) affects millions of people throughout the world and is particularly common among those whose ancestors came from sub-Saharan Africa; Spanish-speaking regions in the Western Hemisphere (South America, the Caribbean, and Central America); Saudi Arabia; India; and Mediterranean countries such as …