Is paclitaxel a mitotic inhibitor?

Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.

Which drugs are classified as mitotic inhibitors?

List of Mitotic inhibitors:

Drug Name Avg. Rating Reviews
Taxotere (Pro) Generic name: docetaxel 5.0 9 reviews
Halaven (Pro) Generic name: eribulin 9.4 9 reviews
Taxol (Pro) Generic name: paclitaxel 8.4 7 reviews
Abraxane Generic name: paclitaxel protein-bound 6.2 6 reviews

Which anticancer drug is mitotic inhibitor?

Colchicine. Colchicine is an alkaloid derived from the autumn crocus (Colchicum autumnale). It inhibits mitosis by inhibiting microtubule polymerization.

Does paclitaxel inhibit cell division?

Paclitaxel inhibited mitotic progression with a median inhibitory concentration of 4 nM, a concentration equivalent to the median cytotoxic concentration, without arresting cells in mitosis.

What problems can be caused by mitotic inhibitors?

The major toxicities of these four groups are bone marrow depression, nausea and vomiting, mucositis, and diarrhea. Daunorubicin, doxorubicin, epirubicin, idarubicin, and, to a lesser extent, mitoxantrone cause cardiac toxicity. Mitomycin and bleomycin cause pulmonary fibrosis.

What does mitotic activity mean?

Listen to pronunciation. (my-TAH-tik ak-TIH-vih-tee) Having to do with the presence of dividing (proliferating) cells. Cancer tissue generally has more mitotic activity than normal tissues.

Why is Taxol given weekly?

Weekly paclitaxel after standard adjuvant chemotherapy with doxorubicin and cyclophosphamide improves disease-free and overall survival in women with breast cancer.

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How effective is Taxol?

Nevertheless, response rates with weekly paclitaxel up to 86% have been achieved with single-agent therapy, up to 87% with combination therapy and up to 100% when combined with radiotherapy.

What is mitotic inhibitors used for?

A type of drug that blocks cell growth by stopping mitosis (cell division). They are used to treat cancer. Also called antimitotic agent.

What are anticancer drugs called?

Antineoplastic drugs are medications used to treat cancer. Antineoplastic drugs are also called anticancer, chemotherapy, chemo, cytotoxic, or hazardous drugs.

What is an event that results from mitosis but not meiosis?

The daughter cells produced by mitosis are identical, whereas the daughter cells produced by meiosis are different because crossing over has occurred. The events that occur in meiosis but not mitosis include homologous chromosomes pairing up, crossing over, and lining up along the metaphase plate in tetrads.

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