Paclitaxel partly induces cell death through disrupting mitosis by binding to and stabilizing the microtubule proteins. When paclitaxel binds to the microtubules, it essentially freezes them in place, preventing the separation of chromosomes during cell division.
Does paclitaxel inhibit cell division?
Paclitaxel inhibited mitotic progression with a median inhibitory concentration of 4 nM, a concentration equivalent to the median cytotoxic concentration, without arresting cells in mitosis.
Why does taxol inhibit mitosis?
Together these observations strongly indicate that the mechanism of inhibition of mitosis by taxol is due to inhibition of microtubule dynamics.
How does paclitaxel affect cancer cells?
Background: Compelling evidence indicates that paclitaxel kills cancer cells through the induction of apoptosis. Paclitaxel binds microtubules and causes kinetic suppression (stabilization) of microtubule dynamics.
Does paclitaxel affect meiosis?
They are involved in cell division (by mitosis and meiosis) and are the major constituents of mitotic spindles. Paclitaxel partly induces cell death through disrupting mitosis by binding to and stabilizing the microtubule proteins.
How successful is paclitaxel?
Nevertheless, response rates with weekly paclitaxel up to 86% have been achieved with single-agent therapy, up to 87% with combination therapy and up to 100% when combined with radiotherapy.
What are the side effects of paclitaxel?
Nausea, vomiting, diarrhea, mouth sores, muscle/joint pain, numbness/tingling/burning of the hands/feet, flushing, dizziness, or drowsiness may occur. If any of these effects persist or worsen, tell your doctor promptly. Temporary hair loss may occur.
Why is Taxol given weekly?
Weekly paclitaxel after standard adjuvant chemotherapy with doxorubicin and cyclophosphamide improves disease-free and overall survival in women with breast cancer.
What is source of Taxol?
The natural source of taxol is the inner bark of several Taxus species, but it accumulates at a very low concentration and with a prohibitively high cost of extraction. Another problem is that the use of inner bark for taxol production implies the destruction of yew trees.