How does chromatin remodeling happen?

Such remodeling is principally carried out by 1) covalent histone modifications by specific enzymes, e.g., histone acetyltransferases (HATs), deacetylases, methyltransferases, and kinases, and 2) ATP-dependent chromatin remodeling complexes which either move, eject or restructure nucleosomes. …

How do chromatin remodelers change the structure of the chromatin?

In contrast to histone modifications, which do not require energy, chromatin remodeling is an energy-driven process in which chromatin remodelers use the energy of ATP hydrolysis to change the nucleosome structure [49, 50]. … After DNA replication, chromatin remodelers pack genomic DNA into nucleosomes.

What is the mechanism of action of a chromatin remodeling complex?

Results from biochemical and structural studies of the RSC chromatin-remodeling complex prompt a proposal for the remodeling mechanism: RSC binding to the nucleosome releases the DNA from the histone surface and initiates DNA translocation (through one or a small number of DNA base pairs); ATP binding completes

Which is a form of chromatin remodeling?

The regulated alteration of chromatin structure, termed ‘chromatin remodeling’, can be accomplished by covalent modification of histones or by the action of ATP-dependent remodeling complexes. A variety of mechanisms can be used to remodel chromatin; some act locally on a single nucleosome and others act more broadly.

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What are the three types of chromatin?

Euchromatin is the lightly packed form of chromatin, whereas heterochromatin refers to the condensed form. Euchromatin and heterochromatin are functionally and structurally distinct, and have key roles in the transcription and expression of genes.

Is chromatin easy to read and copy or easy to move?

After an m-RNA message is transcribed from the DNA it is edited.


In dividing? OR non-dividing cells? IN NON-DIVIDING CELLS IN DIVIDING CELLS
Easy to read & copy? OR Easy to move? EASY TO READ & COPY EASY TO MOVE

How is chromatin remodeling determined?

Nucleosome mobilization by chromatin remodeling factors is easily detected by observing band disappearance in gel, which in turn provides evidence for histone octamer displacement.

Does chromatin have RNA?

Whether RNA itself plays a direct structural role in chromatin is, however, not known. Here, we report results indicating that RNA plays a general structural role in eukaryotic chromatin. Our results indicate that purified chromatin contains significant amounts of RNA (2%–5% of total nucleic acids).

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