Frequent question: How drug affect the behavior of chromosomes during mitosis?

When applied in anaphase, both drugs stopped or slowed poleward chromosome movements, usually reversibly. When applied near the end of prophase, both drugs often prevented one or more bivalents in the cell from attaching to the spindle.

Can drugs affect chromosomes?

[19] This findings from our area indicates the following important points, as drug users results is significant increase in the frequency of cells with chromosome damage as compared with that observed in the general population.

What is responsible for chromosome movement during mitosis?

Powering chromosome movement (microtubules) The most prominent structure in a mitotic cell is the bipolar spindle (made up of microtubules and associated motor proteins), which provides the force to move chromosomes and thereby bring about their segregation.

What happens when chromosomes undergo mitosis?

During mitosis, a eukaryotic cell undergoes a carefully coordinated nuclear division that results in the formation of two genetically identical daughter cells. … Then, at a critical point during interphase (called the S phase), the cell duplicates its chromosomes and ensures its systems are ready for cell division.

Which drug causes destruction of chromosomes?

Of all the subjects reported to have chromosome damage, only 18 of the 108 (16.67 percent) were exposed to pure LSD. The frequency of individuals with chromosomal damage reported among illicit drug users was more than triple that associated with the use of pharmacologically pure LSD.

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How a genetic variation will affect drug response effect?

Because of their genetic makeup, some people process (metabolize) drugs slowly. As a result, a drug may accumulate in the body, causing toxicity. Other people metabolize drugs so quickly that after they take a usual dose, drug levels in the blood never become high enough for the drug to be effective.

What is the behavior of chromosomes in meiosis?

The typical behavior of chromosomes in meiosis is that homologous pairs synapse, recombine, and then separate at anaphase I. At anaphase II, sister chromatids separate. However, studies of small chromosomes in maize derived from a variety of sources typically have failure of sister chromatid cohesion at anaphase I.

How does mitosis happen?

Mitosis is the process in cell division by which the nucleus of the cell divides (in a multiple phase), giving rise to two identical daughter cells. Mitosis happens in all eukaryotic cells (plants, animals, and fungi). It is the process of cell renewal and growth in a plant, animal or fungus.

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