Carriers of the sickle cell trait (ie, heterozygotes who carry one HbS allele and one normal adult hemoglobin [HbA] allele) have some resistance to the often-fatal malaria caused by Plasmodium falciparum.
What can be a benefit of having a gene for sickle cell anemia?
The main advantage of gene therapy is that it is a potentially curative treatment, like bone marrow transplant. After the therapy, one would no longer be at risk of health crises from sickle cell disease.
What if a person only inherits one gene for sickle cell anemia?
People who have inherited one sickle cell gene and one normal gene have SCT. This means the person won’t have the disease, but will be a trait “carrier” and can pass it on to his or her children.
What are some positive effects of sickle cell?
There are positive effects at the whole organism level
Carriers of the sickle cell allele are resistant to malaria, because the parasites that cause this disease are killed inside sickle-shaped blood cells.
What is the life expectancy for someone with sickle cell anemia?
With a national median life expectancy of 42–47 years, people with sickle cell disease (SCD) face many challenges, including severe pain episodes, stroke, and organ damage.
Can a child have sickle cell trait if neither parent has it?
Your child would have to inherit two sickle cell genes to have sickle cell disease. So if your child’s father does not have the sickle cell gene, your child can’t get sickle cell disease. But if your child’s father has the sickle cell gene, your child can get sickle cell disease.
Can two sickle cell carriers marry?
When both individuals are sickle cell carriers, the church discourages them from marrying. Some church denominations, especially in Enugu state, go further and refuse to wed couples when both individuals are sickle cell carriers.
Can a person with sickle cell have a baby?
Can Women With Sickle Cell Disease Have A Healthy Pregnancy? Yes, with early prenatal care and careful monitoring throughout the pregnancy, a woman with SCD can have a healthy pregnancy. However, women with SCD are more likely to have problems during pregnancy that can affect their health and that of their unborn baby.