Which are mitotic inhibitors?

A type of drug that blocks cell growth by stopping mitosis (cell division). They are used to treat cancer. Also called antimitotic agent.

What drugs are mitotic inhibitors?

Examples of mitotic inhibitors frequently used in the treatment of cancer include paclitaxel, docetaxel, vinblastine, vincristine, and vinorelbine. Colchicine and griseofulvin are mitotic inhibitors used in the treatment of gout and toenail fungus, respectively.

Is cisplatin a mitotic inhibitor?

Chemotherapeutic agents include alkylating agents (cyclophosphamides), anthracycline antibiotics (doxorubicin), platinum compounds (cisplatin), mitotic inhibitors (vincristine), antimetabolites (5-fluorouracil), camptothecin derivatives (topotecan), biological response modifiers (interferon), and hormonal therapies ( …

Is etoposide a mitotic inhibitor?

In conventional chemotherapy, there are several types of drugs which cause lethal damage in proliferating cells: mitotic inhibitors (vincristine, paclitaxel, tamoxifen, etc.), topoisomerase inhibitors (irinotecan, camptothecin, etoposide, etc.), antimetabolites (5-fluorouracil, cytarabine, methotrexate, etc.), and …

What is mitotic spindle inhibitors?

A mitotic inhibitor is a drug that inhibits mitosis, or cell division. These drugs disrupt microtubules, which are structures that pull the chromosomes apart when a cell divides. … Thus, cancer cells are more sensitive to inhibition of mitosis than normal cells.

What do mitotic inhibitors do?

A type of drug that blocks cell growth by stopping mitosis (cell division). They are used to treat cancer. Also called antimitotic agent.

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What does mitotic activity mean?

Listen to pronunciation. (my-TAH-tik ak-TIH-vih-tee) Having to do with the presence of dividing (proliferating) cells. Cancer tissue generally has more mitotic activity than normal tissues.

How do microtubule inhibitors work?

Microtubule inhibitors (MTI) such as taxanes, vinca alkaloids, and epothilones stabilize or destabilize microtubules, thereby suppressing microtubule dynamics required for proper mitotic function, effectively blocking cell cycle progression and resulting in apoptosis.

What chemical is used in chemotherapy?

There are several types of alkylating agents used in chemotherapy treatments: Mustard gas derivatives: Mechlorethamine, Cyclophosphamide, Chlorambucil, Melphalan, and Ifosfamide. Ethylenimines: Thiotepa and Hexamethylmelamine.

Which is the most variable stage of cell cycle?

Introduction to the Cell Cycle

G1 is typically the longest and most variable cell-cycle phase. When cells are “born” at cytokinesis, they are roughly half the size they were before mitosis, and during G1, they grow back toward an optimal size.

Is fludarabine a chemotherapy?

Fludarabine is a chemotherapy drug and has the brand name Fludara. Fludarabine is mainly used to treat chronic lymphocytic leukaemia (CLL).

What is the cost of etoposide?

ETOPOSIDE, VP-16 is a chemotherapy drug. It is used to treat small cell lung cancer and other cancers. The lowest GoodRx price for the most common version of etoposide is around $614.26, 66% off the average retail price of $1,812.55.

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