Phenotypic screening is a strategy used in drug discovery to identify molecules with the ability to alter a cell’s phenotype. Animal models and cell-based assays are both strategies used to identify these molecules. “An image is worth a thousand words is something we hear often.
What is phenotypic profiling?
Phenotypic profiling analyses as many features as possible in a single cell in order to select for robust, meaningful features. These functional and morphometric data are extracted to generate an individual cell profile. The advantage of this multiparametric assay is reduced human bias.
What are the different methods of drug discovery?
For drug discovery, two different complementary approaches can be applied: classical pharmacology, also known as phenotypic drug discovery, which is the historical basis of drug discovery, and reverse pharmacology or target-based drug discovery .
Which method is useful for drug discovery?
The method of choice in drug-discovery in the past two decades has been target-based screening. Now, phenotypic screening is beginning to emerge as a preferable method. Phenotypic screening involves the screening of a set of candidate molecules being tested based on its ability to exert effects.
What was the first synthetic drug?
The first synthetic drug, chloral hydrate, was discovered in 1869 and introduced as a sedative-hypnotic; it is still available today in some countries.
How is AI used in drug discovery?
AI can assist in structure-based drug discovery by predicting the 3D protein structure because the design is in accordance with the chemical environment of the target protein site, thus helping to predict the effect of a compound on the target along with safety considerations before their synthesis or production.
What are the 4 stages of drug development?
Content current as of:
- Step 1: Discovery and Development.
- Step 2: Preclinical Research.
- Step 3: Clinical Research.
- Step 4: FDA Drug Review.
- Step 5: FDA Post-Market Drug Safety Monitoring.
What is drug screening?
Drug screening is the process by which potential drugs are identified and optimized before selection of a candidate drug to progress to clinical trials. It can involve screening large libraries of chemicals for a particular biological activity in high-throughput screening assays.