What are mitotic poisons?

Any chemical compound that kills dividing cells. Some mitotic poisons are spindle poisons (q.v.), and others block topoisomerases (q.v.). Poisoned cells are arrested at the spindle or DNA damage checkpoints, and they subsequently undergo apoptosis (q.v.). From: mitotic poison in A Dictionary of Genetics »

Which is toxic to mitotic spindle?

Spindle poisons, such as paclitaxel and vinblastine, exert their potent anti-neoplastic effects through activation of the spindle assembly checkpoint (SAC), thereby arresting cells in mitosis. Unfortunately, only certain cancers are susceptible to these drugs, and many patients fail to respond to treatment.

Are spindles poisonous?

Uses of spindle

Both the leaves and fruit are toxic to humans – the berries having a laxative effect.

Is colchicine a spindle poison?

Colchicine, the classic antimitotic poison, disrupts cell division by preventing proper assembly of microtubules in the mitotic spindle. Colchicine is known to act by binding to tubulin, the heterodimeric subunit of microtubules.

Is spindle good for wildlife?

Spindle is most striking in the autumn when its narrow, oval leaves turn reddish-orange and clusters of bright pink-and-orange berries hang from its twigs. These berries provide food for all kinds of creatures, including mice, birds and even Red Foxes, but are poisonous to us.

Are spindles invasive?

In this most English of landscapes, when its fruit cases are pink and fully ripe, the spindle (Euonymus europaeus) looks at the very least out of place. Any other such temerity at this time of year might be branded a garden escape, some Victorian plant collector’s whimsy or, worse, an invasive species.

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Why is colchicine called mitotic poison?

Colchicine is an alkaloid widely used in plant breeding for doubling the chromosome number. The alkaloid does not allow the formation of spindle because it prevents assembly of microtubules. It is, therefore, called ‘mitotic poison’.

At what stage of mitosis is colchicine effective?

Colchicine is a classical anti-mitotic drug which blocks mitotic cells in metaphase. It binds to soluble tubulin to form tubulin-colchicine complexes in a poorly reversible manner, which then binds to the ends of microtubules to prevent the elongation of the microtubule polymer.

What is colchicine used to treat?

Colchicine is a medicine for treating inflammation and pain. It can be used to: treat flare-ups (attacks) of gout. prevent increased flare-ups of gout when you first start on a medicine like allopurinol – taken to manage your condition long term.

What is the final product of mitosis?

Mitosis results in two identical daughter cells, whereas meiosis results in four sex cells.

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