Our results suggest that there is a major gene on chromosome 10p implicated in the development of human obesity, and the existence of two further loci influencing leptin levels.
What gene causes obesity?
Rarely, obesity occurs in families according to a clear inheritance pattern caused by changes in a single gene. The most commonly implicated gene is MC4R, which encodes the melanocortin 4 receptor. Changes in MC4R that diminish its function are found in a small fraction (<5%) of obese people in various ethnic groups.
Is obesity a chromosome?
In conclusion, obesity is a highly complex multifactorial clinical phenotype with significant genetic predisposition. So far, several single genes and genomic loci scattered on most of the chromosomes except the Y chromosome have been reported and are involved in the pathogenesis of human obesity.
What genes are found on chromosome 17?
Human chromosome 17 is implicated in a wide range of human genetic diseases. It is home to genes involved in early-onset breast cancer (BRCA1), neurofibromatosis (NF1) and the DNA damage response (TP53 encoding the p53 protein).
Can obesity be cured?
The best way to treat obesity is to eat a healthy, reduced-calorie diet and exercise regularly. To do this you should: eat a balanced, calorie-controlled diet as recommended by your GP or weight loss management health professional (such as a dietitian) join a local weight loss group.
Is there a fat gene?
The fat gene (otherwise known as the FTO gene) has been shown to contribute to the regulation of our appetite and speed of our metabolism. And, would you believe it, everyone has the fat gene! But the extent to which it is likely to affect your weight depends on what variant you have of the gene.
What is the obesity gene called?
The gene they studied is called the FTO gene. A particular variation of the FTO gene has been linked to obesity.
What are the types of obesity?
Body Mass Index
- Overweight (not obese), if BMI is 25.0 to 29.9.
- Class 1 (low-risk) obesity, if BMI is 30.0 to 34.9.
- Class 2 (moderate-risk) obesity, if BMI is 35.0 to 39.9.
- Class 3 (high-risk) obesity, if BMI is equal to or greater than 40.0.
Who obese people?
Obesity is defined as excessive body fat that increases your risk of other health problems. A person with a body mass index (BMI) above 30 is considered obese, while a person with a BMI between 25 and 30 is considered overweight.
Is chromosome 17 a gene?
Chromosome 17 spans more than 83 million base pairs (the building material of DNA) and represents between 2.5 and 3% of the total DNA in cells. Chromosome 17 contains the Homeobox B gene cluster.
|No. of genes||1,124 (CCDS)|
|Centromere position||Submetacentric (25.1 Mbp)|
|Complete gene lists|
What does the 20th chromosome do?
Chromosome 20 likely contains 500 to 600 genes that provide instructions for making proteins. These proteins perform a variety of different roles in the body.