Chemotherapeutic agents include alkylating agents (cyclophosphamides), anthracycline antibiotics (doxorubicin), platinum compounds (cisplatin), mitotic inhibitors (vincristine), antimetabolites (5-fluorouracil), camptothecin derivatives (topotecan), biological response modifiers (interferon), and hormonal therapies ( …
What drugs are mitotic inhibitors?
Examples of mitotic inhibitors frequently used in the treatment of cancer include paclitaxel, docetaxel, vinblastine, vincristine, and vinorelbine. Colchicine and griseofulvin are mitotic inhibitors used in the treatment of gout and toenail fungus, respectively.
What is a mitosis inhibitor chemotherapy drug?
A type of drug that blocks cell growth by stopping mitosis (cell division). They are used to treat cancer. Also called antimitotic agent.
What drug inhibits mitotic spindle formation?
Colchicine is an alkaloid derived from the autumn crocus (Colchicum autumnale). It inhibits mitosis by inhibiting microtubule polymerization.
Which chemotherapy medication is called a mitotic inhibitor because it is cell cycle specific for the M mitosis phase of the cell cycle?
Paclitaxel is a mitotic inhibitor capable of promoting tubulin polymerisation to microtubules and stabilising them. It blocks cell cycle progression in G2–M. It is an approved therapeutic agent in the management of NSCLC, ovarian and breast cancer, and Kaposi sarcoma.
What problems can be caused by mitotic inhibitors?
The major toxicities of these four groups are bone marrow depression, nausea and vomiting, mucositis, and diarrhea. Daunorubicin, doxorubicin, epirubicin, idarubicin, and, to a lesser extent, mitoxantrone cause cardiac toxicity. Mitomycin and bleomycin cause pulmonary fibrosis.
What does mitotic activity mean?
Listen to pronunciation. (my-TAH-tik ak-TIH-vih-tee) Having to do with the presence of dividing (proliferating) cells. Cancer tissue generally has more mitotic activity than normal tissues.
How do VEGF inhibitors work?
When VEGF and other endothelial growth factors bind to their receptors on endothelial cells, signals within these cells are initiated that promote the growth and survival of new blood vessels. Other chemical signals, called angiogenesis inhibitors, interfere with blood vessel formation.
What can stop cell division?
Summary. Aging mammalian cells can stop dividing and enter senescence if they are damaged or have defective telomeres. Senescence protects against tumor formation, and tumor suppressor genes include some that regulate cell division and lead to senescence.
What are the phases of mitosis?
These phases are prophase, prometaphase, metaphase, anaphase, and telophase. Cytokinesis is the final physical cell division that follows telophase, and is therefore sometimes considered a sixth phase of mitosis.
How do anti mitotic drugs work?
Antimitotic drugs activate the spindle assembly checkpoint (SAC), since they disrupt microtubule formation and chromosome segregation resulting in the characteristic mitotic arrest . Since the compounds are disruptive to the correct attachment of microtubules, the cells undergo cell death via apoptosis .