How common is chromosomal translocation?

Chromosomal translocations refer to exchange of chromosomal segments between chromosomes. Translocations are the most common type of structural chromosomal abnormalities seen in the general population, having a frequency of about 1/1000 live births.

How common is a balanced translocation?

Balanced chromosome translocations, in which sections of chromosomes change their geographical position on the chromosomal map without any loss or gain of important genetic material, are an important cause of recurrent miscarriages because they are common; one in 500 people carries a balanced translocation.

What causes chromosome translocation?

Translocations generally result from swapping of chromosomal arms between heterologous chromosomes and hence are reciprocal in nature (Figure 1) (8,9). DNA double-strand breaks (DSBs) are prerequisites for such translocations, although little is known about their generation.

Can you have a healthy baby with balanced translocation?

Natural conception and live birth is possible in cases of balanced translocation, but those with the condition may have more difficulty conceiving and are at a greater risk of recurrent miscarriage than those without it.

How do you know if translocation is balanced?

Sometimes a section from one chromosome of a particular pair changes places with a section from a chromosome of another pair. When the two breaks do not pass through a gene and there is no gain or loss of material when the chromosomes are looked at under a microscope, it is called a balanced translocation.

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How is balanced translocation treated?

There is no cure for balanced translocation, and in most cases, the only adverse effect on health is recurrent miscarriages. 1 For couples affected by balanced translocation, odds are in favor of a successful pregnancy at some point, but repeated miscarriages can obviously be difficult to cope with emotionally.

What does translocation cause?

Chromosomes are structures that carry genes, our units of heredity. When this type of translocation occurs, it can cause flaws in chromosomes. In another type of translocation, two chromosomes trade pieces with each other. Genetic translocations can cause serious disorders, including a type of leukemia.

What is an example of translocation?

The translocation in this example is between chromosomes 14 and 21. When a baby is born with this type of translocation chromosome in addition to one normal 14 and two normal 21 chromosomes, the baby will have Down syndrome. This is also called translocation Down syndrome.

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